A new modality to the recently established, material-independent “3D-Painting” process will be introduced. In the current work, the powder component of the 3D-paint is entirely or partly composed of water soluble salts. 3D-painted salt structures can be readily leeched via water washing to create mechanically robust structures with upwards of 95-98% porosity without compromising mechanical properties will be demonstrated. The focus will be on materials and structures 3D-printed from paints containing only salt powders at 25, 50, and 70 volume% solids loading (remaining solids is medical grade polylactide-co-glycolide; PLGA), that have been leeched prior to use, but briefly discuss how this process can be applied to materials beyond polymers. Each group exhibits distinct mechanical, structural, and biological properties. Elastic moduli range from 1-250 MPa; absorbency ranges from 200-800%. In vitro studies over 28 days show that the low porosity group do not even permit cell adhesion. This is in stark contrast to the high porosity groups that are cell friendly and promote cell adhesion, proliferation, and matrix production. 12-week in vivo results from adult rat critical sized cranial will be shared. Finally, how this system can act as a non-specific-bioactive scaffold/carrier for liquids and gels will be discussed.
- Understand how specific processing schemes can influence the properties and function of common biomedical materials.
- Learn a new approach for incorporating porosity into 3D-printed materials and structures of all types, including metals, alloys, and ceramics.
- Understand the importance of hierarchical porosity in the performance of 3D-printed, implantable biomaterials.